abstract：:The multistep nature of cancer suggested from chemical carcinogenesis studies, epidemiological data and cell culture experiments could be explained by the occurrence of somatic mutations resulting in inappropriate expression of normal cellular sequences which have an intrinsic potential of becoming cancer genes. The d...

journal_title：Anticancer research

authors： Spandidos DA

更新日期：1983-03-01 00:00:00

abstract：:Three histamine H2-receptor antagonists, Cimetidine, Metiamide and Ranitidine, were tested for their inhibitory effect on two experimental bowel cancer models. In the first model mitotic rates were measured in dimethylhydrazine-induced tumors of rat colon and in the second model volumetric changes in human large bowel...

journal_title：Anticancer research

authors： Tutton PJ,Barkla DH

更新日期：1983-01-01 00:00:00

abstract：:The metabolic transformations of labeled pyridoxine by hepatoma cells were studied. Buffalo rats were fed ad libitum a commercially prepared pyridoxine sufficient diet for 20 days at which time they were inoculated intramuscularly with hepatoma 7777 cells in both hind leg muscles. After tumor development, 50 microCi [...

journal_title：Anticancer research

authors： Tryfiates GP

更新日期：1983-01-01 00:00:00

abstract：:The neurogenic rat tumour BT4A was serially transplanted to the dorsum of the right hind leg of BD IX rats. The tumours were treated with water bath heating at 44.0 degrees C for one hour alone or combined with bleomycin or BCNU, both given intraperitoneally at a dose of 20 mg/kg. Bleomycin alone had no effect on tumo...

journal_title：Anticancer research

authors： Dahl O,Mella O

更新日期：1982-11-01 00:00:00

abstract：:This paper reviews the properties and regulation of cation transport during the cell cycle. Extensive modulations occur in both electro-diffusional and non-electro-diffusional cation transport, most prominently during mitosis and G1 phase. These modulations can be related to compositional, structural and dynamic membr...

journal_title：Anticancer research

authors： Boonstra J,Mummery CL,van Zoelen EJ,van der Saag PT,de Laat SW

更新日期：1982-09-01 00:00:00

abstract：:Reduction of nitroblue tetrazolium by blood monocytes was significantly increased following post-operative radiation therapy for breast cancer. Attachment and ingestion of yeast particles by monocytes was not affected. Exposure of purified monocytes in vitro to 13 Gy did not significantly affect NBT reduction of yeas...

journal_title：Anticancer research

authors： Jarstrand C,Petrini B,Wasserman J,Blomgren H,Strender LE

更新日期：1982-07-01 00:00:00

abstract：:5-Fluorouracil (5FU) increases the rate of incorporation of tritiated thymidine (3HTdR) and iododeoxyuridine (125 IUdR) into the cell and its DNA. 5FU has differential effect on metabolism of DNA through its specific action on thymidylate synthetase. Effects of 5FU on the incorporation of other metabolic precursors we...

journal_title：Anticancer research

authors： Vercammen-Grandjean AF,Arnould R,Libert A,Lejeune FJ

更新日期：1982-05-01 00:00:00

abstract：:The incidence of female breast cancer was studied as a function of age in 71 different populations throughout the world. Incidence data was normalized for differences in frequency of occurrence. Median normalized incidence increased exponentially from age 20 to 45. After age 45 the rate of incidence decreased, and we ...

journal_title：Anticancer research

authors： Dix D,Cohen P

更新日期：1982-01-01 00:00:00

abstract：:The effects of supplemental selenium on 7,12-dimethylbenz(a)anthracene (DMBA)-induced and murine mammary tumor virus (MuMTV)-induced mammary tumorigenesis were investigated in BALB/c mice. Selenium (4-10 ppm), administered in the drinking water, inhibited mammary tumor formation in DMBA-treated mice. The higher doses ...

journal_title：Anticancer research

authors： Medina D,Lane H,Shepherd F

更新日期：1981-01-01 00:00:00

abstract：:This article describes previous studies on a unique protein antitumor antibiotic, neocarzinostatin. Namely, its chemical nature, mode of action at molecular and cellular levels, toxicity and pharmacology, and recent results in clinical trials obtained primarily in Japan have been reviewed briefly. ...

journal_title：Anticancer research

authors： Maeda H

更新日期：1981-01-01 00:00:00

abstract：:Brain tumors were induced in inbred Fischer rats (F344) by administration of methylnitrosourea in the drinking water. One of the induced tumors, a pleomorphic glioma (78-219), was established in vitro and propagated as 78FR-G-219 permanent cell line. The tumorigenicity of the established line was investigated by intra...

journal_title：Anticancer research

authors： Stavrou D,Bilzer T,Anzil AP,Hultén M,Kaldrymidou E

更新日期：1981-01-01 00:00:00

abstract：:Chemotherapy for patients with multiple myeloma was individually selected on the basis of antiproliferative drug sensitivity determined in vitro by a clonogenic assay. Myeloma stem cells were preincubated with various cytostatic drugs and allowed to form colonies in a plasma clot culture system. In 21 out of 24 prospe...

journal_title：Anticancer research

authors： Ludwig H,Fritz E

更新日期：1981-01-01 00:00:00

abstract：:Cytotoxicity of L-canavanive, a structural analogue of L-arginine, was tested by means of (1) inhibition of DNA synthesis in Balb/c-3T3 cell line and (2) inhibition of mitosis in peripheral blood lymphocytes in culture. The cytostatic nature of inhibition caused by L-canavanine was indicated by the complete recovery o...

journal_title：Anticancer research

authors： Naha PM

更新日期：1981-01-01 00:00:00